Anticancer agents against malaria: time to revisit?

It's time to revisit Flexner.

Tendons – time to revisit inflammation

It is currently widely accepted among clinicians that chronic tendinopathy is caused by a degenerative process devoid of inflammation. Current treatment strategies are focused on physical treatments, peritendinous or intratendinous injections of blood or blood products and interruption of painful stimuli. Results have been at best, moderately good and at worst a failure. The evidence for non-in...

Anticancer agents targeted to sirtuins.

Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1-7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signa...

Rotational Coronary Angiography: Time to Revisit

Although coronary angiography is considered the gold standard for diagnosis of coronary artery disease, it has many limitations. In standard angiography, the operator acquires multiple views of the coronary arteries in 4-6 projections for the left coronary artery and 2-3 for the right coronary artery to find the diseased area for diagnosis and subsequent treatment of coronary artery disease. Mu...

Energy expenditure in disease: time to revisit?

Knowledge of energy expenditure is especially important in disease, and may in fact help in the understanding of the pathophysiology of wasting associated with disease. Energy requirements in a clinical setting are often 'prescribed' by health professionals, either directly through enteral or parenteral feeding, or perhaps controlled through a hospital diet. Studies initially suggested an incre...